A driver involved in a head-on crash at Wirrina Cove over the weekend has been arrested.

The collision between a Toyota SUV and Audi sedan occurred on Main South Road, Wirrina Cove about 10.30am on Sunday 16 October.

The Toyota driver, a 74-year-old man from Belgium and his passenger, a 73-year-old woman also from Belgium were taken to the Flinders medical Centre with non-life threatening injuries.

The Audi driver, a 46-year-old man from Dover Gardens and his passenger, a 55-year-old Woodcroft man were also taken to the Flinders Medical Centre with non-life threatening injuries.

Main South Road was closed for several hours while emergency services remained at the scene.

As a result of investigations, today police arrested the 74-year-old Belgian man and charged him with aggravated driving without due care. He was bailed to appear in the Christies Beach Magistrates Court tomorrow.

Anyone who witnessed the crash or who has dashcam footage is asked to contact Crime Stoppers on 1800 333 000 or online at www.crimestopperssa.com.au/