Police are investigating a serious crash involving three vehicles overnight, following a high-speed incident where one car allegedly failed to stop for police.

At around 9pm on Wednesday, June 11, officers detected a white Holden Commodore sedan travelling at a dangerous speed of 146 km/h in a 60 km/h zone along Port Elliot Road, Middleton.

Police patrols later sighted the vehicle in Goolwa, where it performed a u-turn. Officers activated their lights and sirens in an attempt to pull the vehicle over, but the driver refused to stop. The pursuit was called off shortly after, as the Commodore entered a 100 km/h zone on Port Elliot Road, heading back towards Middleton.

Just minutes later, emergency services were called to the scene of a three-car collision at the intersection of Port Elliot Road and Boettcher Road.

The 41-year-old alleged driver of the Commodore sustained serious injuries and was transported to hospital. A 65-year-old woman from Goolwa South, driving a Land Rover that rolled in the crash, also required hospital treatment. Both are reported to have non-life-threatening injuries.

The third driver, a 35-year-old man from Goolwa North, was uninjured after his vehicle was clipped during the incident.

All vehicles involved were towed from the scene, and the roadway has since been cleared and reopened to traffic.

Police investigations are ongoing. Charges are expected to be laid against the driver of the Commodore for multiple driving offences.