Update 1907hrs: All roads have reopened following a serious crash at McLaren Vale this afternoon.

About 3.30pm Sunday 25 April emergency services were called to the intersection of Main Road and McMurtrie Road after a Hyundai sedan and a Mitsubishi wagon collided.

Three people in the Hyundai, a 70-year-old woman, 72-year-old woman and 89-year-old woman along with two people in the Mitsubishi, a 77-year-old man and 73-year-old woman were all taken to hospital in a serious but stable condition.

The intersection of Main Road and Johnson Road was closed while Major Crash Investigators attended the scene, but has now been reopened and the cars towed.

Anyone who witnessed the crash who has not yet spoken to police is asked to contact Crime Stoppers South Australia on 1800 333 000 or report on line at www.crimestopperssa.com.au.