Victor Harbor Road has reopened after a serious crash at Mount Jagged this afternoon.

A car and ute collided on Victor Harbor Road, near the intersection of Mosquito Hill Road, Mount Jagged about 2.45pm on Thursday 18 July.

Seven people involved were taken to hospital.

The driver of a Subaru sedan, a 26-year-old Tooperang woman, was airlifted to hospital with life-threatening injuries.

Her passengers, a 26-year-old Tooperang woman and a 7-year-old boy, both sustained non-life-threatening injuries.

The family in the Mitsubishi ute, a 46-year-old male driver and his passengers, a 43-year-old woman, 12-year-old boy and 10-year-old boy, all from Port Noarlunga South, also sustained non-life-threatening injuries.

Major Crash investigators attended the scene and are investigating the circumstances surrounding the crash.

Both vehicles were towed from the scene for examination.

Anyone who witnessed the crash or has dashcam vision that may assist the investigation can pass their details on to Major Crash investigators via Crime Stoppers on 1800 333 000 or online at www.crimestopperssa.com.au